{"id":6365,"date":"2026-07-15T13:42:03","date_gmt":"2026-07-15T11:42:03","guid":{"rendered":"https:\/\/immunologie-kiel.de\/news\/antigen-restricted-candida-albicans-th17-cells-link-oral-gut-immunity-and-adopt-pathogenic-features-during-intestinal-inflammation\/"},"modified":"2026-07-15T13:45:56","modified_gmt":"2026-07-15T11:45:56","slug":"antigen-restricted-candida-albicans-th17-cells-link-oral-gut-immunity-and-adopt-pathogenic-features-during-intestinal-inflammation","status":"publish","type":"news","link":"https:\/\/immunologie-kiel.de\/en\/news\/antigen-restricted-candida-albicans-th17-cells-link-oral-gut-immunity-and-adopt-pathogenic-features-during-intestinal-inflammation\/","title":{"rendered":"Antigen-restricted\u00a0Candida albicans\u00a0Th17 cells link oral-gut immunity and adopt pathogenic features during intestinal inflammation"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"996\" height=\"996\" src=\"https:\/\/immunologie-kiel.de\/wp-content\/uploads\/2026\/07\/ga1_lrg.jpg\" alt=\"\" class=\"wp-image-6363\" srcset=\"https:\/\/immunologie-kiel.de\/wp-content\/uploads\/2026\/07\/ga1_lrg.jpg 996w, https:\/\/immunologie-kiel.de\/wp-content\/uploads\/2026\/07\/ga1_lrg-300x300.jpg 300w, https:\/\/immunologie-kiel.de\/wp-content\/uploads\/2026\/07\/ga1_lrg-150x150.jpg 150w, https:\/\/immunologie-kiel.de\/wp-content\/uploads\/2026\/07\/ga1_lrg-768x768.jpg 768w\" sizes=\"(max-width: 996px) 100vw, 996px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The commensal yeast\u00a0<em>Candida albicans<\/em>\u00a0is a major inducer of human mucosal Th17 cells. How\u00a0<em>C. albicans<\/em>\u00a0drives Th17 cell responses at homeostasis, and whether such responses contribute to inflammatory diseases, remains poorly understood. Here, we showed that\u00a0<em>C. albicans-<\/em>reactive Th17 cells targeted a limited set of proteins enriched in fungal extracellular vesicles. At homeostasis, these cells predominantly resided in the oral mucosa. However, T cell receptor profiling revealed shared clonotypes across oral and gut tissues, with\u00a0<em>C. albicans<\/em>\u00a0being a major driver of this repertoire overlap. In patients with Crohn\u2019s disease,\u00a0<em>C. albicans<\/em>-specific Th17 cells with features of oral priming were enriched in intestinal tissues, where they retained their focused antigen specificity but acquired pathogenic Th17 cell traits. Together, our results reveal a stable, antigen-restricted\u00a0<em>C. albicans<\/em>\u00a0Th17 subset that is shared across mucosal sites and undergoes functional adaptation in the inflamed intestine. These cells represent a potential target for immune modulation in Crohn\u2019s disease. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00264-5\" data-type=\"link\" data-id=\"https:\/\/www.cell.com\/immunity\/fulltext\/S1074-7613(26)00264-5\" target=\"_blank\" rel=\"noreferrer noopener\">Read more<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The commensal yeast\u00a0Candida albicans\u00a0is a major inducer of human mucosal Th17 cells. How\u00a0C. albicans\u00a0drives Th17 cell responses at homeostasis, and whether such responses contribute to inflammatory diseases, remains poorly understood. Here, we showed that\u00a0C. albicans-reactive Th17 cells targeted a limited set of proteins enriched in fungal extracellular vesicles. At homeostasis, these cells predominantly resided in [&hellip;]<\/p>\n","protected":false},"template":"","class_list":["post-6365","news","type-news","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/immunologie-kiel.de\/en\/wp-json\/wp\/v2\/news\/6365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunologie-kiel.de\/en\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/immunologie-kiel.de\/en\/wp-json\/wp\/v2\/types\/news"}],"wp:attachment":[{"href":"https:\/\/immunologie-kiel.de\/en\/wp-json\/wp\/v2\/media?parent=6365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}